Taking Charge of Menopause
by Lynne L. Hall
"I was 40 when I first started having night sweats," says Patti Shields, 42, of Birmingham, Ala. "I'd wake up in the middle
of the night, and even though the air conditioner was running full blast, I'd be covered in sweat."
Shields is talking about menopause, the rite of passage that signals the end of a woman's reproductive years. "Those night
sweats--and the other symptoms I began to notice--suddenly made me feel old. One day I'm a young woman in her prime, and the
next day I'm worrying about whether or not I'm prepared for retirement and thinking about 'getting my affairs in order.' It
was a classic overreaction," she says, laughing.
Medical scholars dispassionately define menopause as "the cessation of menstruation." For women, it is much more than that.
Because menopause marks the end of fertility, many women see it as a time of freedom from menstrual periods and pregnancy.
"Women shouldn't think of menopause as a death sentence," says Holly Richter, M.D., assistant professor of medical/surgical
gynecology at the University of Alabama at Birmingham. "It is a transition from a healthy reproductive life to a healthy nonreproductive
life. If women see themselves not just as a uterus, but instead look at themselves as a whole person, this nonreproductive
life can be as fulfilling as their reproductive years."
Menopause is the result of ovarian failure, which sounds ominous, but is actually a normal part of aging. Over time, the
ovaries gradually lose the ability to produce estrogen and progesterone, the hormones that govern the menstrual cycle. Estrogen
can also protect against several health threats, most notably heart disease and osteoporosis. Loss of these hormones, especially
estrogen, causes hot flashes and other symptoms associated with menopause.
In the United States, the average age of natural menopause--defined as one year without a menstrual period--is 51, but
some women reach menopause in their 40s, and a few in their 60s.
Menopause before age 40 is considered premature menopause. There can be several causes, including genetics or autoimmune
disorders, and a medical evaluation is needed.
Induced menopause can occur at any age due to surgical removal of the ovaries or damage to ovaries from treatments such
as chemotherapy or radiation.
The Journey Begins
Menopause is a gradual process, says Richter, a journey that takes years to navigate. Most women notice their bodies are
changing by their mid-30s. Hormone fluctuations cause disruptions in the menstrual cycle, such as lighter or heavier bleeding,
and longer, shorter or skipped periods.
As ovarian function decreases, hormone production becomes erratic and diminishes, causing the onset of menopausal symptoms.
Most women begin experiencing these symptoms two to 10 years before menstrual periods end. These years mark the "perimenopause."
As estrogen levels wane, many woman experience only a few changes, while others find themselves plagued by the full array,
- Hot flashes--This is the hallmark symptom of menopause, and experts say 85 percent of women will experience
these personal heat waves. Starting in the center of the body, a flash of heat spreads like a wall of flame to the top of
the head, flushing the face, neck and arms a fiery red, and making skin warm to the touch. The flash can last from seconds
to 30 minutes and is accompanied by increased heart rate, shallow breathing, and sweating. A chill and exhaustion usually
follow. Hot flashes can occur as many as 50 times a day.
- Night sweats--These hot flashes that occur during sleep cause a woman to wake drenched in sweat, sometimes
several times a night. Because of these sleep disturbances, daytime fatigue can become a problem.
- Vaginal atrophy--The loss of estrogen causes the tissues of the vagina and vulva to become thin and dry.
Sex often becomes painful. Additionally, the vagina can become inflamed and irritated from a high alkaline content, a condition
called "atrophic vaginitis."
- Urinary tract changes--Thinning of the lining of the urethra and weakening of surrounding pelvic muscles
may lead to more frequent urination, frequent bladder infections, painful urination, sudden urinary urgency, and frequent
urination during the night. Urinary incontinence may also become a problem.
- Loss of libido--In addition to losing their ability to secrete estrogen, the ovaries no longer produce
testosterone--the hormone responsible for sex drive in both men and women. Some women's bodies may produce the tiny amount
needed through the adrenal glands. Many women, however, lose all testosterone, and with it their sex drive.
- Emotional changes--Irritability, mood swings, anxiety, and depression are frequently the result of fluctuating
- Formication--This bizarre symptom, the feeling that ants are crawling over the skin, occurs in about
20 percent of women, according to Lois Jovanovic, M.D., in her book A Woman Doctor's Guide to Menopause.
These changes may continue up to three years following a woman's last menstrual period, a time known as the "climacteric."
Long-Term Health Risks
Since women today live an average of 35 years longer than they did 150 years ago, scientists have only recently come to
understand the long-term outcomes of living without the protective effects of estrogen. Ongoing studies have confirmed these
effects, and women should be aware of them in order to avoid serious health risks.
Cardiovascular disease is the leading killer of American women. Before menopause, estrogen appears to help women maintain
a healthy balance between LDL (bad) and HDL (good) cholesterol, making them six times less likely to experience a heart attack
than men age 50 and younger, according to Jovanovic. Once estrogen is no longer present, LDL levels rise, and atherosclerosis
(narrowing of the arteries) occurs. After menopause, a woman's risk for heart disease is about the same as a man's.
Estrogen also protects a woman against osteoporosis, the bone disease that affects 50 percent of American women over 60.
In osteoporosis, bones become brittle and are easily fractured. It is the cause of the distinctive hump noticed in some elderly
women and of dangerous hip fractures-the twelfth leading cause of death in the United States.
A 1996 study, reported in the medical journal The Lancet suggests estrogen protects against Alzheimer's disease, as well.
The study showed that patients with Alzheimer's were significantly less likely to have taken estrogen following menopause
(7 percent versus 18 percent). Additionally, the study found that four of seven Alzheimer's patients taking daily estrogen
improved on mental test scores.
"It's predicted that the number of Americans with Alzheimer's will double in the next 30 years--affecting up to 14 million
people. It's a major health issue for women, and the fact that estrogen may help prevent the disease is an important finding,"
Other health risks associated with the loss of estrogen include increased risk for ovarian and colon cancer, periodontal
(gum) disease and tooth loss, and cataract formation.
When menopause symptoms begin, a woman should see her doctor to rule out pregnancy or serious health problems such as uterine
cancer. A blood test to assess estrogen status also should be performed.
The most reliable test measures the level of follicle stimulating hormone (FSH), a hormone that is secreted by the pituitary
gland to stimulate estrogen production. Levels of 30 to 40 milli International Units per milliliter (MIU/mL) or above means
a woman has reached menopause. A level in the teens or 20s means there is still partial ovarian function.
If the ovaries are still functioning, many physicians prescribe low-dose contraceptive pills, which regulate periods and
alleviate other symptoms. Because contraceptives can mask menopausal changes, a yearly FSH test should be performed beginning
at age 50 to assess ovary status.
"Once a woman reaches menopause [and ovaries no longer function], we discontinue the contraceptives and consider other
options," Richter says.
Estrogen replacement therapy (ERT) is an effective treatment for menopausal symptoms and has been approved for this use
since the 1940s. During the 1980s, ERT also received approval by the Food and Drug Administration for preventing osteoporosis.
When taken for many years, ERT reduces the risk of wrist, hip and spine fractures by 50 to 75 percent.
Its health benefits don't stop there. Numerous studies suggest possible effectiveness in prevention of heart disease, Alzheimer's,
and other menopause-related conditions. In fact, a study published in the Feb. 1999, issue of The Lancet cited research revealing
that postmenopausal women who use ERT have a 30 to 50 percent lower death rate than those who do not.
Currently ERT is available in pill and transdermal (skin) patch form. Different regimens and dosages are available. Health
status and personal choice determine which is best. Because estrogen causes the buildup of endometrial tissue, and may increase
the risk of cancer, a woman who still has her uterus must also take a progestin, which causes the excess tissue to shed.
Progestins can be taken either cyclically or continuously. In the cyclical regimen, estrogen is taken daily and progesterone
is added for 12 to 14 days of each month. Several days after progesterone is stopped, a woman will usually experience a short
period. Monthly bleeding can be lessened by taking a low dose of progestin with estrogen every day.
ERT may increase the risk for uterine cancer, blood clots, or gallbladder disease. Many studies have evaluated the possibility
of increased breast cancer risk, but results are conflicting. Women taking ERT should perform monthly breast self-exams, says
Richter, and have yearly mammograms after age 50.
Side effects associated with ERT include weight gain, bloating, breast tenderness, and nausea.
The hormones available for ERT are derived from two sources. Premarin (conjugated estrogens), the oldest and still the
most widely prescribed estrogen, is derived from pregnant horse urine. It is approved for both symptom relief and prevention
Other ERTs are plant-derived, and several are available in both pill and patch form. One of the newest to receive FDA approval
is Cenestin (synthetic conjugated estrogens, A), which is synthesized from soy and yam extracts. "Cenestin is approved for
the relief of vasomotor symptoms such as hot flashes," says Lisa Rarick, M.D., director of FDA's division of reproductive
and urologic drug products. "There have been no trials on osteoporosis prevention yet."
Other plant-derived estrogens approved for menopausal symptoms include Alora (estradiol), Climara (estradiol), FemPatch
(17-beta-estradiol), Menest (esterified estrogens), Ortho-est (estropipate), Vivelle (estradiol), and Ogen (estropipate).
Estrace (estradiol), Estraderm (estradiol), and Estratab (esterified estrogens) are plant-based estrogens approved for both
menopausal symptoms and osteoporosis prevention. Estrogen/progesterone combinations also are available in either patch or
Relief from vaginal atrophy can be attained with a variety of FDA-approved vaginal creams containing estrogen, such as
Estrace (estradiol), Ortho Dienestrol (dienestrol), Premarin (conjugated estrogens), and Ogen (estropipate). Estring (17-beta-estradiol),
a vaginal ring, also is available. The ring is inserted into the upper vagina, where it provides a consistent low dose of
estrogen for three months. Since only a small amount of the hormones provided by the ring and creams is absorbed into the
system, they are not believed to increase the risk for endometrial or breast cancer. Estradiol rings do not alleviate symptoms
such as hot flashes, and are not believed to provide protection against menopause-related diseases such as osteoporosis and
In 1997, FDA approved Evista (raloxifene), a drug that mimics estrogen's protective effects on the bones and heart. Clinical
studies show that this drug, one of a new class called selective estrogen receptor modulators (SERMs), increases bone density
and reduces levels of LDL, or "bad" cholesterol. But it does not cause the endometrial buildup or breast changes that may
increase cancer risk. It does carry the risk of blood clots and is not effective for menopausal symptoms such as hot flashes.
More studies are in progress to determine the long-term effects and efficacy of Evista and other SERMs.
Miacalcin (calcitonin) and Fosamax (alendronate) are two drugs FDA has approved for treating osteoporosis. Miacalcin is
effective in women who are not candidates for HRT and who are at least five years postmenopausal and are suffering from osteoporosis.
Available as a nasal spray, it has been found to increase bone density.
Fosamax reduces the activity of the cells that cause bone loss and thereby increases the amount of bone present. Both drugs
can cause side effects, making a consultation with a physician essential.
Some women may prefer to "let nature take its course" and choose not to take prescription hormones. Others turn to alternative
remedies touted to relieve menopausal symptoms and protect against related diseases.
One type of foods being extensively researched are "phytoestrogens." These are natural compounds similar in chemical structure
to estrogen that may produce estrogen-like effects in menopausal women.
Of these compounds, the isoflavones found in soy protein seem to be the most promising. Studies being conducted at Wake
Forest University Baptist Medical Center in Winston-Salem, N.C., show the phytoestrogens in soy protein to be just as effective
as Premarin in monkeys at limiting the formation of atherosclerosis, a major cause of heart disease. Additionally, women who
added 20 grams of soy protein to their diets reported less intense menopausal symptoms, such as hot flashes and night sweats.
"We believe soy may offer many of the benefits of estrogen replacement therapy without the risks," says study leader Greg
The benefits of soy protein first drew interest when studies showed that in Asian countries, where diets are high in soy,
both the incidence of breast cancer and the heart disease mortality rate are four times lower than in the United States. In
addition, Asian women report fewer hot flashes and night sweats during menopause. These women get about 30 to 50 milligrams
of isoflavones daily, the levels found in half a cup of soy milk or tofu or a quarter cup of roasted soy nuts.
In 1998, FDA proposed allowing health claims about the role soy protein may play in reducing the risk of heart disease
on the labels of foods containing soy protein. Studies show that 25 grams of soy protein per day may lower blood cholesterol
Making some lifestyle changes can help women increase longevity and avoid the health risks associated with menopause. The
American Heart Association recommends limiting total fat intake to no more than 30 percent of calories, cholesterol to no
more than 300 milligrams daily, and salt to no more than 3,000 milligrams daily. The association also recommends eating lean
meats, low-fat dairy products, and at least five servings of fruits and vegetables daily. (See "Eating for a Healthy Heart"
on FDA's Easy Reader Website at www.fda.gov/opacom/lowlit/englow.html.)
In addition to a heart-healthy diet, exercise that includes cardiovascular and weight-bearing workouts is good for the
heart and bones. The action of muscle on bone helps to increase bone density, so exercises such as weight training, running,
walking, or jogging are important. Check with a doctor before beginning an exercise program.
"Preparing for the change of life is essential, since women are living one third or more of their lives in menopause,"
says Richter. "Together with their physicians they can minimize the associated health risks and help sustain a good quality
of life throughout their nonreproductive years."
Lynne L. Hall is a writer based in Birmingham, Ala.