FEMALE HORMONE REPLACEMENT

Metabolite of estrogen is neuroprotective
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DHEA is produced in the brain (and elsewhere).  Other studies have shown a protective quality for stroke victims.  This study confirmed it for rat pups brains slices which were maintained and then exposed to oxygen deprivation for 3 hours.  DHEA significantly reduced hippocampal cell loss.   This is consistent with other studies of the sex hormones estradiol and testosterone (and probably others) whose elderly users function at a higher level than those who don’t take them, and they have a lower risk of neuro-degenerative diseases. JK has been taking DHEA sublingually since 2006 and testosterone since 2004.  

The article refers to the benefits of epiandrosterone (EPIA).  EPIA is a metabolite of testosterone and dihydrotestosterone.  EPIA is also produced from DHEA and other androgens.  Two metabolites of EPIA, and thus of the aforementioned hormones, have significant neuroprotective properties.  Probably, though not listed in the Wikipedia article, and the structurally related female hormones estradiol, estrone, estriol  (E2, E1, E3).  

Fully at http://onlinelibrary.wiley.com/doi/10.1046/j.1460-9568.2003.02734.x/full

 

Cognitive protection by steroids

European Journal of Neuroscience ENJ Vol 18, no.1, 117-124

7-Hydroxylated epiandrosterone (7-OH-EPIA) reduces ischaemia-induced neuronal damage both in vivo and in vitro

Ashley K. Pringle, 1 Werner Schmidt, 2 Jackie K. Deans, 1 Ernst Wulfert, 3 Klaus G. Reymann 2,4 and Lars E. Sundstrom 1

  1 Clinical Neurosciences, Centre for Neurosciences, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, Southampton SO16 7PX, UK   2 Research Institute Applied Neurosciences, Magdeburg, Germany   3 Hunter-Fleming Ltd, Regus House, Temple Quay, Bristol BS1 6EA, UK   4 Leibniz Institute for Neurobiology, Magdeburg, Germany

Correspondence: Dr Ashley Pringle, as above.
E-mail:
akp1@soton.ac.uk

Cognitive protection by steroids

European Journal of Neuroscience ENJ Vol 18, no.1, 117-124

7-Hydroxylated epiandrosterone (7-OH-EPIA) reduces ischaemia-induced neuronal damage both in vivo and in vitro

Ashley K. Pringle, 1 Werner Schmidt, 2 Jackie K. Deans, 1 Ernst Wulfert, 3 Klaus G. Reymann 2,4 and Lars E. Sundstrom 1

  1 Clinical Neurosciences, Centre for Neurosciences, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, Southampton SO16 7PX, UK   2 Research Institute Applied Neurosciences, Magdeburg, Germany   3 Hunter-Fleming Ltd, Regus House, Temple Quay, Bristol BS1 6EA, UK   4 Leibniz Institute for Neurobiology, Magdeburg, Germany

Correspondence: Dr Ashley Pringle, as above.
E-mail:
akp1@soton.ac.uk

Recent evidence suggests that steroids such as oestradiol reduce ischaemia-induced neurodegeneration in both in vitro and in vivo models [lack of oxygen-blood causing reduced functions].  A cytochrome P450 enzyme termed cyp7b that 7-hydroxylates many steroids is expressed at high levels in brain, although the role of 7-hydroxylated steroids is unknown. We have tested the hypothesis that the steroid-mediated neuroprotection is dependent on the formation of 7-hydroxy metabolites. Organotypic hippocampal slice cultures were prepared from Wistar rat pups and maintained in vitro for 14 days. Cultures were then exposed to 3 h hypoxia [lack of oxygen as during a stroke] and neuronal damage assessed 24 h later using propidium iodide fluorescence as a marker of cell damage.  Neurodegeneration occurred primarily in the CA1 pyramidal cell layer. The steroids oestradiol, dehydroepiandrosterone and epiandrosterone (EPIA) were devoid of neuroprotective efficacy when present at 100 nm pre-, during and post-hypoxia. The 7-hydroxy metabolites of  EPIA, 7α-OH-EPIA and 7β-OH-EPIA significantly reduced neurotoxicity at 100 nm and 10 nm. 7β-OH-EPIA was also neuroprotective in two in vivo rat models of cerebral ischaemia: 0.1 mg/kg 7β-OH-EPIA significantly reduced hippocampal cell loss in a model of global forebrain ischaemia, whereas 0.03 mg/kg was neuroprotective in a model of focal ischaemia even when administration was delayed until 6 h after the onset of ischaemia. Taken together, these data demonstrate that 7-hydroxylation of steroids confers neuroprotective efficacy, and that 7β-OH-epiandrosterone represents a novel class of neuroprotective compounds with potential for use in acute neurodegenerative diseases.


Received 24 April 2003, accepted 30 April 2003

 

Another study (double blind) found that 7-keto DHEA in an organic preparation with a cocktail of herbs in an 8 week period produced significant weight loss (mean SD loss, 2.15 2.38 kg, but only 0.72 2.12 kg for placebo group) .

At http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VS8-467SPMX-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_version=1&_urlVersion=0&_userid=10&md5=10235d4c9984971a7fd29b7a4e2e4672

Published by Elsevier Science, accepted February 2002.  

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