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ASPIRIN CHEAP, BEST NASID

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When profits are the measure of performance the public suffers.  Drug companies are trying to replace cheap generic drugs with the latest patented expensive preparations.  Such is the case with aspirin:  VIOXX is an aspirin replacement which has resulted in over 150,000 deaths, and it was never shown to relieve pain any better than aspirin.  Both aspirin and VIOXX are COX-2 inhibitors.  The hype for sales was that VIOX was better than aspirin because it is a COX-2 inhibitor--but

aspirin is also. 

    For a illustrated account of COX-2 inhibition by aspirin http://www.aspirin-foundation.com/what/chemistry.html

 

WHICH NSAID, IBUPROFIN OR ASPIRIN?

 

ASPIRIN’S PRINCIPLE BENEFITS:

 1)      VERY SIGNIFICANTLY LOWERS THE INCIDENT OF HEART ATTACKS BY REDUCING CLOTTING

2)      CUTS COLON-CANCER DEATH RATE BY 50%

3)      MARKEDLY REDUCES THE INCIDENT OF BREAST CANCER

4)  MARKEDLY REDUCES CESAREAN SECTION

5)  IT IS CHEAP!

Why Take Ibuprofen

1)  it has a better reputation than aspirin among the non-medical public. 

2)      because of this doctors are more likely to proscribe ibuprofen. 

3)      it is inexpensive compared to the more exotic NSAIDS. 

4)      it works.  {NSAIDS is the Non-Steroidal Anti-Inflammatory Drugs--a family with over 20 prescription members}

 

Why Take Aspirin

1) it has been used for a longer period of time and has no major side effects other than intestinal bleeding, and this can be avoid quite effectively by taking coated aspirin, where they.

2) it costs a fraction of Ibuprofen. 

3)  those women taking aspirin regularly while pregnant have under one-forth the incident of caesarean section (5.6% versus 23.9% in a meta-study). 

4)  it lowers the incident of colon cancer approximately 50% (a retrospect study of over 600,000 people).  

5)  it lowers the incident of breast cancer

6)      it dramatically lowers the incident of heart attacks—so much so that doctors routinely recommend taking one-a-day for those who are in the high risk group.

7)      Survival rate for prostate cancer increases 

 

Gastrointestinal Bleeding

  Both Ibuprofen and aspirin cause gastrointestinal bleeding because they are chemical that are irritating and the dosages is high (325 MG or more for aspirin, 400 & 800 MG for Ibuprofen).  In one of the typical ploys to increase profits, Ibuprofen is touted as being less upsetting to the stomach and less likely to cause bleeding.  However, Ibuprofen is coated, and the comparison is to uncoated aspirin.   When comparing likes to likes (coated versus coated) there is no difference. 

 

Costs

  Aspirin can be purchased for a penny a piece in a discount store, and large pharmacies carry a low-price brand in addition to Bayer.  There is no advantage to buying a more expensive brand of acetasalasylic acid.  Ibuprofen sells for at least 10 times the price per dose when compared to those carried by a discount store.

 

Pain Relief

  In general pain diminishes over time, that even acetopmetaphin seems to work.  The family of NSAID (non-steroidal anti inflammatory drugs) is effective for pain resulting from swelling by modestly reducing swelling.  The expectations greatly exceed the reality.  They lack any effect upon the system of nerve sensor resulting in pain—an ability of the opiates.  Most pains diminish naturally within an hour—whether a drug is taken or not.

  

Ways the Two Are Essentially Equal

First, they work.  Second, they both cause stomach bleeding.  Third, on a dose basis they equally lower prostaglandins, a blood factor involved in clotting and by this mechanism they reduce blood clots and consequently the incident of strokes caused by a blood clot and heart attacks so caused.  About 85% of the strokes are a result of a blood clot and 60% of the heart attacks. 

 

But why take a drug that costs more, has not been shown to be more effective, and whose side effects have not been as carefully monitored???    This article was posted 18 months before the VIOXX diseaster.

 

FLASH (December 04), Naproxin, which has been an over-the-counter NSAID since 1976, has been shown to double the incident of coronary events (like VIOXX)