The prophylaxis use of anticoagulants
(primarily warfarin
and Plavix) after major surgery is not
justified given the infrequency of adverse thrombosis associated with the surgery.
They also found the journal articles
overstated the risk of pulmonary embolism, and thus risk of side effect
compared to benefit entail that such drug intervention is not justified. “For this reason guidelines which recommend
their routine use to prevent death after hip replacement are not justified.”
The study
failed to consider the effects of anticoagulants on
the rate of wound healing given the important role of forming blood clots.
http://www.bjj.boneandjoint.org.uk/content/78-B/6/863.abstract October 11, 1993 JAMA Internal Medicine, Vol.
153. No/ 19
THROMBOPROPHYLAXIS AND DEATH AFTER TOTAL
HIP REPLACEMENT
1.
D. W. Murray, MD,
FRCS, Consultant Orthopaedic Surgeon1;
2.
A. R. Britton, MSc,
Research Fellow2; and
3.
C. J. K. Bulstrode, MCh,
FRCS, Clinical Reader, Honorary Consultant Orthopaedic Surgeon1
+Author Affiliations
- 1Nuffield
Department of Orthopaedic Surgery, University of Oxford, Nuffield
Orthopaedic Centre, Windmill Road, Headington, Oxford OX3 7LD, UK.
- 2Department
of Public Health and Policy, London School of Hygiene and Tropical
Medicine, University of London, Keppel Street, London, UK.
1.
Correspondence should be sent to Mr D. W. Murray.
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